No game has seen its complexion change more over the last month than this one. The Melvin Gordon holdout has continued throughout the preseason. Derwin James is out for most of the year, removing one of the NFL's elite defensive playmakers from the equation in this game. And then…yeah, Andrew Luck retired two weeks before the start of the season.
Last season, the Colts played at the fastest pace in the NFL (the Chargers, by the way, played at the slowest pace), but Frank Reich is one of the four or five most adaptable coaches in the NFL . . .